Efficacy of ebastine, cetirizine, and loratadine in histamine cutaneous challenges
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چکیده
منابع مشابه
Efficacy of ebastine, cetirizine, and loratadine in histamine cutaneous challenges.
BACKGROUND Few studies have compared the antihistaminic effect of ebastine at 20 mg/day (maximal recommended daily dose) with the effect found for other antihistamines in human pharmacologic models. OBJECTIVE To compare the inhibition of the histamine-induced skin reaction produced by ebastine (20 mg/day) with that produced by cetirizine (10 mg/day), loratadine (10 mg/day), or placebo in a do...
متن کاملEffects of acrivastine, loratadine and cetirizine on histamine-induced wheal and flare responses.
It is accepted that studies evaluating histamine-induced wheal and flare reactions in the skin represent a simple and reliable method for demonstrating pharmacodynamic activity and pharmacokinetics of the H1-receptor antagonists. In this study, the effects of single oral doses of acrivastine (8 mg), loratadine (10 mg) and cetirizine (10 mg) on the histamine-induced wheal and flare reactions wer...
متن کاملAssessment of efficacy and impact on work productivity and attendance after a mandatory switch to generic second-generation antihistamines: results of a patient survey in Norway
BACKGROUND In 2006, the Norwegian Medicines Agency mandated a switch from desloratadine, ebastine, or fexofenadine to cetirizine or loratadine in patients with allergic rhinitis (AR) or chronic urticaria (CU). In an online survey, patients whose medication was switched assessed the impact on efficacy, fatigue, and work productivity/attendance. METHODS Allergy patients in Norway completed a 25...
متن کاملcomparison of loratadine and cetirizine in perennial allergic rhinitis
background: allergic rhinitis (ar) represents a global health problem, affecting 5-50% of the population worldwide and numerous classes of pharmacological agents are available for its treatment. two more popular of these drugs are loratadine and cetirizine. there are few direct comparator studies between these two drugs with inconsistent results. m aterials and methods: a randomized, double-bli...
متن کاملSimultaneous determination of loratadine, desloratadine and cetirizine by capillary zone electrophoresis.
PURPOSE The aim of the study was the development of a simple and rapid analytical procedure for the determination of the most frequently used antihistamine derivatives. METHODS A capillary zone electrophoretic method was developed for the simultaneous separation of loratadine, desloratadine and cetirizine. Efforts were focused primarly on the optimisation of the experimental parameters: buffe...
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ژورنال
عنوان ژورنال: Annals of Allergy, Asthma & Immunology
سال: 2002
ISSN: 1081-1206
DOI: 10.1016/s1081-1206(10)61952-7